Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1

Inna Nusinzon; Curt M. Horvath

doi:10.1073/pnas.2433987100

Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1

Inna Nusinzon, Curt M. Horvath^*

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

210 Scopus citations

Abstract

The use of histone deacetylase (HDAC) inhibitors has revealed an essential role for deacetylation in transcription of IFN-responsive genes. The HDAC1 protein associates with both signal transducer and activator of transcription (STAT) 1 and STAT2, and IFN-α stimulation induces deacetylation of histone H4. Inhibition of HDAC1 by small interfering RNA (siRNA) decreases IFN-α responsiveness whereas expression of HDAC1 augments the IFN-α response, demonstrating that HDAC1 modulates IFN-α-induced transcription. Importantly, the innate antiviral response is inhibited in the absence of deacetylase activity. The requirement for deacetylase is shared by IFN-γ transcription response and may represent a general requirement for STAT-dependent gene expression.

Original language	English (US)
Pages (from-to)	14742-14747
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	100
Issue number	25
DOIs	https://doi.org/10.1073/pnas.2433987100
State	Published - Dec 9 2003

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