Interferons: Laboratory to clinic investigations

L. C. Platanias*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Interferons are pleiotropic cytokines that exhibit multiple biological effects on cells and tissues, including antiproliferative, antiviral, and immunomodulatory activities. Despite the well-documented activity of interferons in the treatment of certain malignancies, the precise mechanisms by which these cytokines inhibit malignant cell growth remain unknown. Recently, several laboratory studies have provided important dues on the cellular events elicited during the binding of interferons to their receptors on malignant cells. The continuation and expansion of such studies should help us understand the mechanisms by which interferons elicit their antitumor effects and provide a basis for the development of new strategies in their clinical use.

Original languageEnglish (US)
Pages (from-to)560-565
Number of pages6
JournalCurrent Opinion in Oncology
Issue number6
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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