Interleukin-1: Biology, pathophysiology, and clinical prospects

Leonidas C. Platanias*, Nicholas J. Vogelzang

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

99 Scopus citations


Interleukin-1 (IL-1) is a cytokine with multiple biologic activities. Since its first description in 1972, significant work has been done, leading to an understanding of the biology of IL-1, which plays a central role in many important functions of the immune system. The biologic activities of IL-1 make it an attractive factor for use in clinical oncology, both as an antitumor agent and for the hematologic recovery of cancer patients receiving other forms of therapy. In this review the biologic effects of IL-1 are summarized. The possible involvement of IL-1 in the pathogenesis of some diseases is reviewed. Future prospects for the use of IL-1 in the treatment of malignancies are discussed.

Original languageEnglish (US)
Pages (from-to)621-629
Number of pages9
JournalThe American journal of medicine
Issue number5
StatePublished - Nov 1990

ASJC Scopus subject areas

  • General Medicine


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