Interleukin 10

Whitney W. Stevens*, Larry Borish, John W. Steinke

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
Original languageEnglish (US)
Title of host publicationInflammation and Allergy Drug Design
Number of pages10
ISBN (Print)9781444330144
StatePublished - Jul 27 2011


  • Dendritic cells/M2 macrophages - IL-10, by innate immune cells, as macrophage
  • Expression of IL-10, central to maintenance - of immune nonresponsiveness to allergens
  • IL-10, identified - as a Th2 lymphocyte product
  • IL-10, inhibiting major histocompatibility complex (MHC) class II expression - on APCs and dendritic cells (DCs)
  • Immunotherapy mechanisms, and interleukin 10 - immune deviation from Th2, toward a Th1-like response
  • Interleukin 10 (IL-10), immunoregulatory cytokine - with multiple biologic effects on cell types
  • Interleukin 10 signaling - binding to heterodimer receptor complex, IL-10 receptor 1 and IL-10R2 chains
  • Interleukin 10, and CD4+ lymphocytes - regulatory T lymphocyte families, nTreg, iTreg and Th3 cells
  • Potential utility of direct IL-10 administration - as asthma therapeutic
  • Sources of interleukin 10 - immature DCs and B cells, major sources of IL-10 in humans

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medicine(all)

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