Interleukin-2 production during intravesical bacille Calmette-Guerin therapy for bladder cancer

Timothy L. Ratliff*, Eric O. Haaff, William J. Catalona

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Interleukin-2 (IL-2) was detected in urine but not serum of patients receiving intravesical bacille Calmette-Guerin (BCG) therapy for bladder cancer. IL-2 activity was neutralized by anti-IL-2 antibody. No IL-2 was detected in urine before BCG therapy or from control donors. BCG-induced urine IL-2 peaked 4-8 hr after treatment but was rarely observed after 24 hr. The presence of BCG-induced lymphokines may be associated with antitumor activity.

Original languageEnglish (US)
Pages (from-to)375-379
Number of pages5
JournalClinical Immunology and Immunopathology
Volume40
Issue number2
DOIs
StatePublished - Aug 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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