Intermediate filament associated proteins

Kathleen J. Green; Michael Böhringer; Todd Gocken; Jonathan C.R. Jones

doi:10.1016/S0065-3233(05)70006-1

Intermediate filament associated proteins

Kathleen J. Green^*, Michael Böhringer, Todd Gocken, Jonathan C.R. Jones

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

Intermediate filament associated proteins (IFAPs) coordinate interactions between intermediate filaments (IFs) and other cytoskeletal elements and organelles, including membrane-associated junctions such as desmosomes and hemidesmosomes in epithelial cells, costameres in striated muscle, and intercalated discs in cardiac muscle. IFAPs thus serve as critical connecting links in the IF scaffolding that organizes the cytoplasm and confers mechanical stability to cells and tissues. However, in recent years it has become apparent that IFAPs are not limited to structural crosslinkers and bundlers but also include chaperones, enzymes, adapters, and receptors. IF networks can therefore be considered scaffolding upon which associated proteins are organized and regulated to control metabolic activities and maintain cell homeostasis.

Original language	English (US)
Pages (from-to)	143-202
Number of pages	60
Journal	Advances in Protein Chemistry
Volume	70
DOIs	https://doi.org/10.1016/S0065-3233(05)70006-1
State	Published - 2005

Funding

The authors would like to thank Spiro Getsios for critical reading of the manuscript and Ron Liem and Bishr Omary for helpful discussions, and also our colleagues who shared information prior to its publication. Work in the authors' laboratories is supported by NIH grants RO1 DK60589 , RO1 HL067016, PO1 HL071643, PO1 DE12328 (project #3) to J. Jones and RO1AR41836, RO1 AR43380, and PO1 DE12328 (project #4) to K. Green.

ASJC Scopus subject areas

Biochemistry

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10.1016/S0065-3233(05)70006-1

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title = "Intermediate filament associated proteins",

abstract = "Intermediate filament associated proteins (IFAPs) coordinate interactions between intermediate filaments (IFs) and other cytoskeletal elements and organelles, including membrane-associated junctions such as desmosomes and hemidesmosomes in epithelial cells, costameres in striated muscle, and intercalated discs in cardiac muscle. IFAPs thus serve as critical connecting links in the IF scaffolding that organizes the cytoplasm and confers mechanical stability to cells and tissues. However, in recent years it has become apparent that IFAPs are not limited to structural crosslinkers and bundlers but also include chaperones, enzymes, adapters, and receptors. IF networks can therefore be considered scaffolding upon which associated proteins are organized and regulated to control metabolic activities and maintain cell homeostasis.",

author = "Green, {Kathleen J.} and Michael B{\"o}hringer and Todd Gocken and Jones, {Jonathan C.R.}",

note = "Funding Information: The authors would like to thank Spiro Getsios for critical reading of the manuscript and Ron Liem and Bishr Omary for helpful discussions, and also our colleagues who shared information prior to its publication. Work in the authors' laboratories is supported by NIH grants RO1 DK60589 , RO1 HL067016, PO1 HL071643, PO1 DE12328 (project #3) to J. Jones and RO1AR41836, RO1 AR43380, and PO1 DE12328 (project #4) to K. Green. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2005",

doi = "10.1016/S0065-3233(05)70006-1",

language = "English (US)",

volume = "70",

pages = "143--202",

journal = "Advances in Protein Chemistry",

issn = "0065-3233",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Intermediate filament associated proteins

AU - Green, Kathleen J.

AU - Böhringer, Michael

AU - Gocken, Todd

AU - Jones, Jonathan C.R.

N1 - Funding Information: The authors would like to thank Spiro Getsios for critical reading of the manuscript and Ron Liem and Bishr Omary for helpful discussions, and also our colleagues who shared information prior to its publication. Work in the authors' laboratories is supported by NIH grants RO1 DK60589 , RO1 HL067016, PO1 HL071643, PO1 DE12328 (project #3) to J. Jones and RO1AR41836, RO1 AR43380, and PO1 DE12328 (project #4) to K. Green. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2005

Y1 - 2005

N2 - Intermediate filament associated proteins (IFAPs) coordinate interactions between intermediate filaments (IFs) and other cytoskeletal elements and organelles, including membrane-associated junctions such as desmosomes and hemidesmosomes in epithelial cells, costameres in striated muscle, and intercalated discs in cardiac muscle. IFAPs thus serve as critical connecting links in the IF scaffolding that organizes the cytoplasm and confers mechanical stability to cells and tissues. However, in recent years it has become apparent that IFAPs are not limited to structural crosslinkers and bundlers but also include chaperones, enzymes, adapters, and receptors. IF networks can therefore be considered scaffolding upon which associated proteins are organized and regulated to control metabolic activities and maintain cell homeostasis.

AB - Intermediate filament associated proteins (IFAPs) coordinate interactions between intermediate filaments (IFs) and other cytoskeletal elements and organelles, including membrane-associated junctions such as desmosomes and hemidesmosomes in epithelial cells, costameres in striated muscle, and intercalated discs in cardiac muscle. IFAPs thus serve as critical connecting links in the IF scaffolding that organizes the cytoplasm and confers mechanical stability to cells and tissues. However, in recent years it has become apparent that IFAPs are not limited to structural crosslinkers and bundlers but also include chaperones, enzymes, adapters, and receptors. IF networks can therefore be considered scaffolding upon which associated proteins are organized and regulated to control metabolic activities and maintain cell homeostasis.

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U2 - 10.1016/S0065-3233(05)70006-1

DO - 10.1016/S0065-3233(05)70006-1

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C2 - 15837516

AN - SCOPUS:17444388553

SN - 0065-3233

VL - 70

SP - 143

EP - 202

JO - Advances in Protein Chemistry

JF - Advances in Protein Chemistry

ER -

Intermediate filament associated proteins

Abstract

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ASJC Scopus subject areas

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