Intermediate filament associated proteins

Kathleen J. Green*, Michael Böhringer, Todd Gocken, Jonathan C.R. Jones

*Corresponding author for this work

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Intermediate filament associated proteins (IFAPs) coordinate interactions between intermediate filaments (IFs) and other cytoskeletal elements and organelles, including membrane-associated junctions such as desmosomes and hemidesmosomes in epithelial cells, costameres in striated muscle, and intercalated discs in cardiac muscle. IFAPs thus serve as critical connecting links in the IF scaffolding that organizes the cytoplasm and confers mechanical stability to cells and tissues. However, in recent years it has become apparent that IFAPs are not limited to structural crosslinkers and bundlers but also include chaperones, enzymes, adapters, and receptors. IF networks can therefore be considered scaffolding upon which associated proteins are organized and regulated to control metabolic activities and maintain cell homeostasis.

Original languageEnglish (US)
Pages (from-to)143-202
Number of pages60
JournalAdvances in Protein Chemistry
Volume70
DOIs
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Biochemistry

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