Intermediate filament dynamics

John E. Eriksson*, Puneet Opal, Robert D. Goldman

*Corresponding author for this work

Research output: Contribution to journalArticle

125 Scopus citations

Abstract

The view of intermediate filaments as static cytoskeletal elements is changing. Studies of exogenous intermediate filament proteins, either microinjected or expressed from transfected genes, have demonstrated that a continuous incorporation of subunits into the polymerized filaments is taking place. This incorporation appears to be required for maintaining normal cytoplasmic networks of intermediate filaments. At the post-translational level, phosphorylation is an important factor in regulating dynamic aspects of intermediate filament organization and structure.

Original languageEnglish (US)
Pages (from-to)99-104
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume4
Issue number1
DOIs
StatePublished - Feb 1992

ASJC Scopus subject areas

  • Cell Biology

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