TY - JOUR
T1 - Intermediate filaments and the plasma membrane
AU - Jones, Jonathan C.R.
AU - Kam, Chen Yuan
AU - Harmon, Robert M.
AU - Woychek, Alexandra V.
AU - Hopkinson, Susan B.
AU - Green, Kathleen J.
N1 - Funding Information:
The Jones laboratory is supported by the National Institute of Arthritis andMusculoskeletal and Skin Diseases and the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Numbers RO1 AR054184 and RO1 HL092963. The Green laboratory is supported by the National Institutes of Health under Award Numbers RO1 AR041836, R37 AR43380, RO1 CA122151, a Leducq Transatlantic Network Grant, and the Joseph L. Mayberry endowment. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.We thank David Kelsell, John McGrath, James McMillan, and Cristina Basso for graciously allowing us to use their data in figures presented in this review.
Publisher Copyright:
© 2017 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2017/1
Y1 - 2017/1
N2 - Avariety of intermediate filament (IF) types show intricate association with plasma membrane proteins, including receptors and adhesion molecules. The molecular basis of linkage of IFs to desmosomes at sites of cell-cell interaction and hemidesmosomes at sites of cell-matrix adhesion has been elucidated and involves IF-associated proteins. However, IFs also interact with focal adhesions and cell-surface molecules, including dystroglycan. Through such membrane interactions, it is well accepted that IFs play important roles in the establishment and maintenance of tissue integrity. However, by organizing cell-surface complexes, IFs likely regulate, albeit indirectly, signaling pathways that are key to tissue homeostasis and repair.
AB - Avariety of intermediate filament (IF) types show intricate association with plasma membrane proteins, including receptors and adhesion molecules. The molecular basis of linkage of IFs to desmosomes at sites of cell-cell interaction and hemidesmosomes at sites of cell-matrix adhesion has been elucidated and involves IF-associated proteins. However, IFs also interact with focal adhesions and cell-surface molecules, including dystroglycan. Through such membrane interactions, it is well accepted that IFs play important roles in the establishment and maintenance of tissue integrity. However, by organizing cell-surface complexes, IFs likely regulate, albeit indirectly, signaling pathways that are key to tissue homeostasis and repair.
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U2 - 10.1101/cshperspect.a025866
DO - 10.1101/cshperspect.a025866
M3 - Article
C2 - 28049646
AN - SCOPUS:85009152027
SN - 1943-0264
VL - 9
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
IS - 1
M1 - a025866
ER -