Intermediate filaments mediate cytoskeletal crosstalk

Lynne Chang*, Robert D. Goldman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

299 Scopus citations


Intermediate filaments, actin-containing microfilaments and microtubules are the three main cytoskeletal systems of vertebrate and many invertebrate cells. Although these systems are composed of distinctly different proteins, they are in constant and intimate communication with one another. Understanding the molecular basis of this cytoskeletal crosstalk is essential for determining the mechanisms that underlie many cell-biological phenomena. Recent studies have revealed that intermediate filaments and their associated proteins are important components in mediating this crosstalk.

Original languageEnglish (US)
Pages (from-to)601-613
Number of pages13
JournalNature Reviews Molecular Cell Biology
Issue number8
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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