Intermediate filaments: not so tough after all

Omar Skalli*, Ying Hao Chou, Robert D. Goldman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


The dynamic properties of cellular protein polymers such as microtubules and microfilaments depend to a large extent on the cell's capacity to modify rapidly the exchange rate between polymerized and unpolymerized pools of subunits. Until quite recently the dynamic nature of intermediate filaments was underestimated because of their biochemical stability in vitro and a paucity of studies on their characteristics in vivo. However, the recent studies described in this review show that the karyoskeletal and cytoskeletal structures that assemble from many intermediate filament proteins possess the properties expected of dynamic protein polymer networks.

Original languageEnglish (US)
Pages (from-to)308-312
Number of pages5
JournalTrends in Cell Biology
Issue number10
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Cell Biology


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