Intermittent etanercept therapy in pediatric patients with psoriasis

Elaine C. Siegfried, Lawrence F. Eichenfield, Amy S. Paller, David Pariser, Kara Creamer, Gregory Kricorian

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Background: Stopping and restarting etanercept is well tolerated in adult psoriasis, but little is known about intermittent use in pediatric psoriasis. Objective: We sought to assess safety and efficacy of etanercept administered intermittently in children with psoriasis. Methods: At study entry, patients were 4 to 17 years old with moderate to severe stable plaque psoriasis (Psoriasis Area and Severity Index [PASI] score ≥ 12). After an initial 12-week, double-blind period and a 24-week, open-label period, eligible patients (ie, achieved 75% improvement in PASI response from baseline [PASI 75]) were re-randomized to a 12-week, double-blind withdrawal-retreatment period: patients received placebo (withdrawal) or etanercept as long as they maintained PASI 75; otherwise, they were retreated with open-label etanercept (retreatment). Results: The 138 patients who entered the withdrawal-retreatment period were re-randomized equally between placebo and etanercept. In the group treated with blinded or open-label etanercept, 52 of 65 (80%; observed data) patients maintained or regained PASI 75 at the end of the 12-week period. In all, 45 of 64 (70%) patients on blinded etanercept maintained PASI 75 at every study visit during the 12-week period, compared with 35 of 65 (54%) patients who did so on blinded placebo. No patient had a serious adverse event, serious infection, or withdrew from study because of an adverse event. Limitations: Small study and short observation period are limitations. Conclusion: During the final 12-week withdrawal-retreatment period of this 48-week study, intermittent etanercept therapy appeared safe, with no patients experiencing a serious adverse event or serious infection, and effective, with 80% of patients on etanercept maintaining or regaining PASI 75 at the end of the 12-week period.

Original languageEnglish (US)
Pages (from-to)769-774
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume63
Issue number5
DOIs
StatePublished - Nov 2010

Keywords

  • etanercept
  • intermittent therapy
  • pediatric plaque psoriasis

ASJC Scopus subject areas

  • Dermatology

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