Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer

Wooram Park; Sin Jung Park; Soojeong Cho; Heejun Shin; Young Seok Jung; Byeongdu Lee; Kun Na; Dong Hyun Kim

doi:10.1021/jacs.6b04875

Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer

Wooram Park, Sin Jung Park, Soojeong Cho, Heejun Shin, Young Seok Jung, Byeongdu Lee^*, Kun Na, Dong Hyun Kim

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

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Abstract

We developed a thermoswitchable polymeric photosensitizer (T-PPS) by conjugating PS (Pheophorbide-a, PPb-a) to a temperature-responsive polymer backbone of biocompatible hydroxypropyl cellulose. Self-quenched PS molecules linked in close proximity by π-π stacking in T-PPS were easily transited to an active monomeric state by the temperature-induced phase transition of polymer backbones. The temperature-responsive intermolecular interaction changes of PS molecules in T-PPS were demonstrated in synchrotron small-angle X-ray scattering and UV-vis spectrophotometer analysis. The T-PPS allowed switchable activation and synergistically enhanced cancer cell killing effect at the hyperthermia temperature (45 °C). Our developed T-PPS has the considerable potential not only as a new class of photomedicine in clinics but also as a biosensor based on temperature responsiveness.

Original language	English (US)
Pages (from-to)	10734-10737
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	138
Issue number	34
DOIs	https://doi.org/10.1021/jacs.6b04875
State	Published - Aug 31 2016

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/jacs.6b04875

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title = "Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer",

abstract = "We developed a thermoswitchable polymeric photosensitizer (T-PPS) by conjugating PS (Pheophorbide-a, PPb-a) to a temperature-responsive polymer backbone of biocompatible hydroxypropyl cellulose. Self-quenched PS molecules linked in close proximity by π-π stacking in T-PPS were easily transited to an active monomeric state by the temperature-induced phase transition of polymer backbones. The temperature-responsive intermolecular interaction changes of PS molecules in T-PPS were demonstrated in synchrotron small-angle X-ray scattering and UV-vis spectrophotometer analysis. The T-PPS allowed switchable activation and synergistically enhanced cancer cell killing effect at the hyperthermia temperature (45 °C). Our developed T-PPS has the considerable potential not only as a new class of photomedicine in clinics but also as a biosensor based on temperature responsiveness.",

author = "Wooram Park and Park, {Sin Jung} and Soojeong Cho and Heejun Shin and Jung, {Young Seok} and Byeongdu Lee and Kun Na and Kim, {Dong Hyun}",

note = "Funding Information: This work was supported by four grants R01CA141047, R21CA173491, R21EB017986, and R21CA185274 from the NCI and NIBIB. This research was also supported by the Basic Research Laboratory (BRL ) Program ( no . 2015R1A4A1042350), through the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP). B.L. was supported by MICCoM as part of the Computational Materials Sciences Program funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences, Materials Sciences and Engineering Division. This work used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under contract no. DE-AC02-06CH11357. Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

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AU - Cho, Soojeong

AU - Shin, Heejun

AU - Jung, Young Seok

AU - Lee, Byeongdu

AU - Na, Kun

AU - Kim, Dong Hyun

N1 - Funding Information: This work was supported by four grants R01CA141047, R21CA173491, R21EB017986, and R21CA185274 from the NCI and NIBIB. This research was also supported by the Basic Research Laboratory (BRL ) Program ( no . 2015R1A4A1042350), through the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP). B.L. was supported by MICCoM as part of the Computational Materials Sciences Program funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences, Materials Sciences and Engineering Division. This work used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under contract no. DE-AC02-06CH11357. Publisher Copyright: © 2016 American Chemical Society.

PY - 2016/8/31

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N2 - We developed a thermoswitchable polymeric photosensitizer (T-PPS) by conjugating PS (Pheophorbide-a, PPb-a) to a temperature-responsive polymer backbone of biocompatible hydroxypropyl cellulose. Self-quenched PS molecules linked in close proximity by π-π stacking in T-PPS were easily transited to an active monomeric state by the temperature-induced phase transition of polymer backbones. The temperature-responsive intermolecular interaction changes of PS molecules in T-PPS were demonstrated in synchrotron small-angle X-ray scattering and UV-vis spectrophotometer analysis. The T-PPS allowed switchable activation and synergistically enhanced cancer cell killing effect at the hyperthermia temperature (45 °C). Our developed T-PPS has the considerable potential not only as a new class of photomedicine in clinics but also as a biosensor based on temperature responsiveness.

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Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer

Abstract

ASJC Scopus subject areas

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