Abstract
Radioembolization with 90Y microspheres represents a novel transarterial radiation treatment for liver tumors. The purpose of this pilot study was to evaluate the findings of postimplantation PET/CT of 90Y glass microspheres. Methods: Three patients with hepatocellular carcinoma and 2 patients with liver metastases (1 neuroendocrine, 1 colorectal) underwent PET/CT after radioembolization. Four patients underwent imaging at 1 mo to assess response and confirm PET/CT findings; 1 patient underwent PET/CT at 4 d after 90Y implantation. Patients were followed for adverse events. Results: Standard PET/CT enabled the localization of 90Y glass microspheres for all patients. None of the patients experienced adverse events related to nontarget deposition. Conclusion: Standard PET/CT may be used to assess the localization of 90Y glass microspheres. This approach provides a simple, rapid, and universally applicable method of confirming microsphere deposition. With further validation, this technique may potentially become the standard of care for confirming microsphere distribution.
Original language | English (US) |
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Pages (from-to) | 72-76 |
Number of pages | 5 |
Journal | Journal of Nuclear Medicine |
Volume | 52 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2011 |
Keywords
- Bremsstrahlung
- Hepatocellular carcinoma
- PET/CT
- Radioembolization
- Radiotherapy
- Y microspheres
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging