Internal pair production of 90Y permits hepatic localization of microspheres using routine PET: proof of concept

Vanessa L. Gates, Abdulredha A.H. Esmail, Karen Marshall, Stewart Spies, Riad Salem*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


Radioembolization with 90Y microspheres represents a novel transarterial radiation treatment for liver tumors. The purpose of this pilot study was to evaluate the findings of postimplantation PET/CT of 90Y glass microspheres. Methods: Three patients with hepatocellular carcinoma and 2 patients with liver metastases (1 neuroendocrine, 1 colorectal) underwent PET/CT after radioembolization. Four patients underwent imaging at 1 mo to assess response and confirm PET/CT findings; 1 patient underwent PET/CT at 4 d after 90Y implantation. Patients were followed for adverse events. Results: Standard PET/CT enabled the localization of 90Y glass microspheres for all patients. None of the patients experienced adverse events related to nontarget deposition. Conclusion: Standard PET/CT may be used to assess the localization of 90Y glass microspheres. This approach provides a simple, rapid, and universally applicable method of confirming microsphere deposition. With further validation, this technique may potentially become the standard of care for confirming microsphere distribution.

Original languageEnglish (US)
Pages (from-to)72-76
Number of pages5
JournalJournal of Nuclear Medicine
Issue number1
StatePublished - Jan 1 2011


  • Bremsstrahlung
  • Hepatocellular carcinoma
  • PET/CT
  • Radioembolization
  • Radiotherapy
  • Y microspheres

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Internal pair production of 90Y permits hepatic localization of microspheres using routine PET: proof of concept'. Together they form a unique fingerprint.

Cite this