International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology

Anna Nowak-Węgrzyn*, Mirna Chehade, Marion E. Groetch, Jonathan M. Spergel, Robert A. Wood, Katrina Allen, Dan Atkins, Sami Bahna, Ashis V. Barad, Cecilia Berin, Terri Brown Whitehorn, A. Wesley Burks, Jean Christoph Caubet, Antonella Cianferoni, Marisa Conte, Carla Davis, Alessandro Fiocchi, Kate Grimshaw, Ruchi Gupta, Brittany HofmeisterJ. B. Hwang, Yitzhak Katz, George N. Konstantinou, Stephanie A. Leonard, Jennifer Lightdale, Sean McGhee, Sami Mehr, Stefano Miceli Sopo, Giovanno Monti, Antonella Muraro, Stacey Katherine Noel, Ichiro Nomura, Sally Noone, Hugh A. Sampson, Fallon Schultz, Scott H. Sicherer, Cecilia C. Thompson, Paul J. Turner, Carina Venter, A. Amity Westcott-Chavez, Matthew Greenhawt

*Corresponding author for this work

Research output: Contribution to journalArticle

157 Scopus citations

Abstract

Food protein–induced enterocolitis (FPIES) is a non-IgE cell- mediated food allergy that can be severe and lead to shock. Despite the potential seriousness of reactions, awareness of FPIES is low; high-quality studies providing insight into the pathophysiology, diagnosis, and management are lacking; and clinical outcomes are poorly established. This consensus document is the result of work done by an international workgroup convened through the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology and the International FPIES Association advocacy group. These are the first international evidence-based guidelines to improve the diagnosis and management of patients with FPIES. Research on prevalence, pathophysiology, diagnostic markers, and future treatments is necessary to improve the care of patients with FPIES. These guidelines will be updated periodically as more evidence becomes available.

Original languageEnglish (US)
Pages (from-to)1111-1126.e4
JournalJournal of Allergy and Clinical Immunology
Volume139
Issue number4
DOIs
StatePublished - Apr 1 2017

Keywords

  • Food protein–induced enterocolitis syndrome
  • guidelines
  • non–IgE-mediated food allergy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Nowak-Węgrzyn, A., Chehade, M., Groetch, M. E., Spergel, J. M., Wood, R. A., Allen, K., Atkins, D., Bahna, S., Barad, A. V., Berin, C., Brown Whitehorn, T., Burks, A. W., Caubet, J. C., Cianferoni, A., Conte, M., Davis, C., Fiocchi, A., Grimshaw, K., Gupta, R., ... Greenhawt, M. (2017). International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology. Journal of Allergy and Clinical Immunology, 139(4), 1111-1126.e4. https://doi.org/10.1016/j.jaci.2016.12.966