@article{184fc0ba65e346afaa691df7cee69a69,
title = "International Guillain-Barr{\'e} Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barr{\'e} syndrome",
abstract = "Guillain-Barr{\'e} syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multicenter cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included within 2 weeks after onset of weakness. Information about demography, preceding infections, clinical features, diagnostic findings, treatment, course, and outcome is collected. In addition, cerebrospinal fluid and serial blood samples for serum and DNA is collected at standard time points. The original aim was to include at least 1,000 patients with a follow-up of 1–3 years. Data are collected via a web-based data entry system and stored anonymously. IGOS started in May 2012 and by January 2017 included more than 1,400 participants from 143 active centers in 19 countries across 5 continents. The IGOS data/biobank is available for research projects conducted by expertise groups focusing on specific topics including epidemiology, diagnostic criteria, clinimetrics, electrophysiology, antecedent events, antibodies, genetics, prognostic modeling, treatment effects, and long-term outcome of GBS. The IGOS will help to standardize the international collection of data and biosamples for future research of GBS.",
keywords = "Guillain-Barr{\'e} syndrome, biomarkers, diagnosis, outcome, prognosis, treatment",
author = "{the IGOS Consortium} and Jacobs, {Bart C.} and {van den Berg}, Bianca and Christine Verboon and Govindsinh Chavada and Cornblath, {David R.} and Gorson, {Kenneth C.} and Thomas Harbo and Hartung, {Hans Peter} and Hughes, {Richard A.C.} and Susumu Kusunoki and {van Doorn}, {Pieter A.} and Willison, {Hugh J.} and Jacobs, {B. C.} and Hughes, {R. A.C.} and Cornblath, {D. R.} and Gorson, {K. C.} and Hartung, {H. P.} and S. Kusunoki and {van Doorn}, {P. A.} and Willison, {H. J.} and {van Woerkom}, M. and {van den Berg}, B. and C. Verboon and J. Roodbol and Jacobs, {B. C.} and Reisin, {R. C.} and Reddel, {S. W.} and Z. Islam and B. Islam and Mohammad, {Q. D.} and {van den Bergh}, P. and Feasby, {T. E.} and Wang, {Y. Z.} and T. Harbo and Y. P{\'e}r{\'e}on and Hartung, {H. P.} and Lehmann, {H. C.} and E. Dardiotis and E. Nobile-Orazio and S. Kusunoki and N. Shahrizaila and Jacobs, {B. C.} and {van den Berg}, B. and C. Verboon and K. Bateman and I. Illa and Querol, {L. A.} and Hsieh, {S. T.} and Willison, {H. J.} and S. Ajroud-Driss",
note = "Funding Information: The IGOS study protocol was developed without external financial support. The development of a web-based data entry support was supported by funding from the GBS-CIDP Foundation International (https://www.gbs-cidp.org/). Additional funding to support the conduct of IGOS for specific countries or projects was received from gain (http://www.gaincharity.org.uk/), Erasmus MC, Rotterdam, The Netherlands, University of Glasgow, Glasgow, UK, Grifols, CSL Behring, Shire Pharmaceuticals and Annexon. IGOS is scientifically independent, and the funding agencies have no influence on the study and infrastructure design of IGOS, nor on the collection, statistical analysis and interpretation of the data collected in IGOS, nor on the writing, publication of manuscripts or other presentations based on these data. Publisher Copyright: {\textcopyright} 2017 Peripheral Nerve Society",
year = "2017",
month = jun,
doi = "10.1111/jns.12209",
language = "English (US)",
volume = "22",
pages = "68--76",
journal = "Journal of the Peripheral Nervous System",
issn = "1085-9489",
publisher = "Wiley-Blackwell",
number = "2",
}