International Liver Transplantation Society Consensus Statement on Immunosuppression in Liver Transplant Recipients

Michael Charlton, Josh Levitsky, Bashar Aqel, John O'Grady, Julie Hemibach, Mary Eugenia Rinella, John Fung, Marwan Ghabril, Ray Thomason, Patrizia Burra, Ester Coelho Little, Marina Berenguer, Abraham Shaked, James Trotter, John Roberts, Manuel Rodriguez-Davalos, Mohamed Rela, Elizabeth Pomfret, Caroline Heyrend, Juan Gallegos-OrozcoFaouzi Saliba

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Effective immunosupression management is central to achieving optimal outcomes in liver transplant recipients. Current immunosuppression regimens and agents are highly effective in minimizing graft loss due to acute and chronic rejection but can also produce a substantial array of toxicities. The utilization of immunosuppression varies widely, contributing to the wide disparities in posttransplant outcomes reported between transplant centers. The International Liver Transplantation Society (ILTS) convened a consensus conference, comprised of a global panel of expert hepatologists, transplant surgeons, nephrologists, and pharmacologists to review the literature and experience pertaining to immunosuppression management to develop guidelines on key aspects of immunosuppression. The consensus findings and recommendations of the ILTS Consensus guidelines on immunosuppression in liver transplant recipients are presented in this article.

Original languageEnglish (US)
Pages (from-to)727-743
Number of pages17
JournalTransplantation
Volume102
Issue number5
DOIs
StatePublished - May 1 2018

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Immunosuppression
Liver
Transplants
Guidelines
Liver Transplantation
Transplant Recipients

ASJC Scopus subject areas

  • Transplantation

Cite this

Charlton, Michael ; Levitsky, Josh ; Aqel, Bashar ; O'Grady, John ; Hemibach, Julie ; Rinella, Mary Eugenia ; Fung, John ; Ghabril, Marwan ; Thomason, Ray ; Burra, Patrizia ; Little, Ester Coelho ; Berenguer, Marina ; Shaked, Abraham ; Trotter, James ; Roberts, John ; Rodriguez-Davalos, Manuel ; Rela, Mohamed ; Pomfret, Elizabeth ; Heyrend, Caroline ; Gallegos-Orozco, Juan ; Saliba, Faouzi. / International Liver Transplantation Society Consensus Statement on Immunosuppression in Liver Transplant Recipients. In: Transplantation. 2018 ; Vol. 102, No. 5. pp. 727-743.
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abstract = "Effective immunosupression management is central to achieving optimal outcomes in liver transplant recipients. Current immunosuppression regimens and agents are highly effective in minimizing graft loss due to acute and chronic rejection but can also produce a substantial array of toxicities. The utilization of immunosuppression varies widely, contributing to the wide disparities in posttransplant outcomes reported between transplant centers. The International Liver Transplantation Society (ILTS) convened a consensus conference, comprised of a global panel of expert hepatologists, transplant surgeons, nephrologists, and pharmacologists to review the literature and experience pertaining to immunosuppression management to develop guidelines on key aspects of immunosuppression. The consensus findings and recommendations of the ILTS Consensus guidelines on immunosuppression in liver transplant recipients are presented in this article.",
author = "Michael Charlton and Josh Levitsky and Bashar Aqel and John O'Grady and Julie Hemibach and Rinella, {Mary Eugenia} and John Fung and Marwan Ghabril and Ray Thomason and Patrizia Burra and Little, {Ester Coelho} and Marina Berenguer and Abraham Shaked and James Trotter and John Roberts and Manuel Rodriguez-Davalos and Mohamed Rela and Elizabeth Pomfret and Caroline Heyrend and Juan Gallegos-Orozco and Faouzi Saliba",
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Charlton, M, Levitsky, J, Aqel, B, O'Grady, J, Hemibach, J, Rinella, ME, Fung, J, Ghabril, M, Thomason, R, Burra, P, Little, EC, Berenguer, M, Shaked, A, Trotter, J, Roberts, J, Rodriguez-Davalos, M, Rela, M, Pomfret, E, Heyrend, C, Gallegos-Orozco, J & Saliba, F 2018, 'International Liver Transplantation Society Consensus Statement on Immunosuppression in Liver Transplant Recipients', Transplantation, vol. 102, no. 5, pp. 727-743. https://doi.org/10.1097/TP.0000000000002147

International Liver Transplantation Society Consensus Statement on Immunosuppression in Liver Transplant Recipients. / Charlton, Michael; Levitsky, Josh; Aqel, Bashar; O'Grady, John; Hemibach, Julie; Rinella, Mary Eugenia; Fung, John; Ghabril, Marwan; Thomason, Ray; Burra, Patrizia; Little, Ester Coelho; Berenguer, Marina; Shaked, Abraham; Trotter, James; Roberts, John; Rodriguez-Davalos, Manuel; Rela, Mohamed; Pomfret, Elizabeth; Heyrend, Caroline; Gallegos-Orozco, Juan; Saliba, Faouzi.

In: Transplantation, Vol. 102, No. 5, 01.05.2018, p. 727-743.

Research output: Contribution to journalReview article

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AU - Charlton, Michael

AU - Levitsky, Josh

AU - Aqel, Bashar

AU - O'Grady, John

AU - Hemibach, Julie

AU - Rinella, Mary Eugenia

AU - Fung, John

AU - Ghabril, Marwan

AU - Thomason, Ray

AU - Burra, Patrizia

AU - Little, Ester Coelho

AU - Berenguer, Marina

AU - Shaked, Abraham

AU - Trotter, James

AU - Roberts, John

AU - Rodriguez-Davalos, Manuel

AU - Rela, Mohamed

AU - Pomfret, Elizabeth

AU - Heyrend, Caroline

AU - Gallegos-Orozco, Juan

AU - Saliba, Faouzi

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Y1 - 2018/5/1

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AB - Effective immunosupression management is central to achieving optimal outcomes in liver transplant recipients. Current immunosuppression regimens and agents are highly effective in minimizing graft loss due to acute and chronic rejection but can also produce a substantial array of toxicities. The utilization of immunosuppression varies widely, contributing to the wide disparities in posttransplant outcomes reported between transplant centers. The International Liver Transplantation Society (ILTS) convened a consensus conference, comprised of a global panel of expert hepatologists, transplant surgeons, nephrologists, and pharmacologists to review the literature and experience pertaining to immunosuppression management to develop guidelines on key aspects of immunosuppression. The consensus findings and recommendations of the ILTS Consensus guidelines on immunosuppression in liver transplant recipients are presented in this article.

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