International Union of Pharmacology. XXXV. The glucagon receptor family

Kelly E. Mayo, Laurence J. Miller, Dominique Bataille, Stéphane Dalle, Burkhard Göke, Bernard Thorens, Daniel J. Drucker*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

413 Scopus citations


Peptide hormones within the secretin-glucagon family are expressed in endocrine cells of the pancreas and gastrointestinal epithelium and in specialized neurons in the brain, and subserve multiple biological functions, including regulation of growth, nutrient intake, and transit within the gut, and digestion, energy absorption, and energy assimilation. Glucagon, glucagon-like peptide-1, glucagon-like peptide-2, glucose-dependent insulinotropic peptide, growth hormone-releasing hormone and secretin are structurally related peptides that exert their actions through unique members of a structurally related G protein-coupled receptor class 2 family. This review discusses advances in our understanding of how these peptides exert their biological activities, with a focus on the biological actions and structural features of the cognate receptors. The receptors have been named after their parent and only physiologically relevant ligand, in line with the recommendations of the International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR).

Original languageEnglish (US)
Pages (from-to)167-194
Number of pages28
JournalPharmacological Reviews
Issue number1
StatePublished - Mar 2003

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology


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