Interpreting neurologic outcomes in a changing trial design landscape: An analysis of heartware left ventricular assist device using a hybrid intention to treat population

Claudius Mahr*, Duc Thinh Pham, Nahush A. Mokadam, Scott C. Silvestry, Jennifer Cowger, Michael S. Kiernan, David A. D'Alessandro, Erin E. Coglianese, Muhammad Faraz Masood, Robert L. Kormos, Mary V. Jacoski, Jeffrey J. Teuteberg

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Randomized controlled trials can provide optimal clinical evidence to assess the benefits of new devices, and it is these data that often shape device usage in real-world practice. However, individual clinical trial results sometimes appear discordant for the same device, and alternative devices are sometimes not employed in similar patient populations. To make sound evidence-based decisions, clinicians routinely rely on cross-trial comparisons from different trials of similar but not identical patient populations to assess competing technology when head-to-head randomized comparisons are unavailable.

Original languageEnglish (US)
Pages (from-to)293-296
Number of pages4
JournalASAIO Journal
Volume65
Issue number3
DOIs
StatePublished - Mar 1 2019

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Keywords

  • advanced heart failure
  • left ventricular assist device
  • stroke

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Mahr, C., Thinh Pham, D., Mokadam, N. A., Silvestry, S. C., Cowger, J., Kiernan, M. S., D'Alessandro, D. A., Coglianese, E. E., Faraz Masood, M., Kormos, R. L., Jacoski, M. V., & Teuteberg, J. J. (2019). Interpreting neurologic outcomes in a changing trial design landscape: An analysis of heartware left ventricular assist device using a hybrid intention to treat population. ASAIO Journal, 65(3), 293-296. https://doi.org/10.1097/MAT.0000000000000931