Interrelationships between plasma homovanillic acid and indices of dopamine turnover in multiple brain areas during haloperidol and saline administration

John G. Csernansky; Deborah E. Barnes; Elisabeth P. Bellows; Leon Lombrozo

doi:10.1016/0024-3205(90)90076-4

Interrelationships between plasma homovanillic acid and indices of dopamine turnover in multiple brain areas during haloperidol and saline administration

John G. Csernansky^*, Deborah E. Barnes, Elisabeth P. Bellows, Leon Lombrozo

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Haloperidol or saline was administered to rats daily for 1, 8, 15 or 22 days. During haloperidol, but not saline administration, changes in plasma homovanillic acid (HVA) concentrations were correlated with changes in nucleus accumbens HVA. Haloperidol administration also had a significant effect on the intercorrelation of dopamine (DA) concentrations and indices of DA turnover across multiple brain areas. In particular, intercorrelations of HVA concentrations among DA terminal brain areas (i.e. striatum, nucleus accumbens, and olfactory tubercle) occurred only during haloperidol treatment.

Original language	English (US)
Pages (from-to)	707-713
Number of pages	7
Journal	Life Sciences
Volume	46
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(90)90076-4
State	Published - 1990

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(90)90076-4

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@article{06c07859ea0a46fdb0cf865187449fe8,

title = "Interrelationships between plasma homovanillic acid and indices of dopamine turnover in multiple brain areas during haloperidol and saline administration",

abstract = "Haloperidol or saline was administered to rats daily for 1, 8, 15 or 22 days. During haloperidol, but not saline administration, changes in plasma homovanillic acid (HVA) concentrations were correlated with changes in nucleus accumbens HVA. Haloperidol administration also had a significant effect on the intercorrelation of dopamine (DA) concentrations and indices of DA turnover across multiple brain areas. In particular, intercorrelations of HVA concentrations among DA terminal brain areas (i.e. striatum, nucleus accumbens, and olfactory tubercle) occurred only during haloperidol treatment.",

author = "Csernansky, {John G.} and Barnes, {Deborah E.} and Bellows, {Elisabeth P.} and Leon Lombrozo",

note = "Funding Information: This work was supported by a grant from the Scottish Rite Schizophrenia Research Program, N.M.J., U.S.A., the NIMH (MH-30854) to the VA-Stanford Mental Health Clinical Research Center at Stanford University, and a special grant of the Medical Research Service of the Veterans Administration (now Department of Veterans Affairs) to the Schizophrenia Biologic Research Center (SBRC) at the Palo Alto VA Medical Center. The authors thank Pamela J. Eiliott for manuscript preparation and editorial advice.",

year = "1990",

doi = "10.1016/0024-3205(90)90076-4",

language = "English (US)",

volume = "46",

pages = "707--713",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "10",

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TY - JOUR

T1 - Interrelationships between plasma homovanillic acid and indices of dopamine turnover in multiple brain areas during haloperidol and saline administration

AU - Csernansky, John G.

AU - Barnes, Deborah E.

AU - Bellows, Elisabeth P.

AU - Lombrozo, Leon

N1 - Funding Information: This work was supported by a grant from the Scottish Rite Schizophrenia Research Program, N.M.J., U.S.A., the NIMH (MH-30854) to the VA-Stanford Mental Health Clinical Research Center at Stanford University, and a special grant of the Medical Research Service of the Veterans Administration (now Department of Veterans Affairs) to the Schizophrenia Biologic Research Center (SBRC) at the Palo Alto VA Medical Center. The authors thank Pamela J. Eiliott for manuscript preparation and editorial advice.

PY - 1990

Y1 - 1990

N2 - Haloperidol or saline was administered to rats daily for 1, 8, 15 or 22 days. During haloperidol, but not saline administration, changes in plasma homovanillic acid (HVA) concentrations were correlated with changes in nucleus accumbens HVA. Haloperidol administration also had a significant effect on the intercorrelation of dopamine (DA) concentrations and indices of DA turnover across multiple brain areas. In particular, intercorrelations of HVA concentrations among DA terminal brain areas (i.e. striatum, nucleus accumbens, and olfactory tubercle) occurred only during haloperidol treatment.

AB - Haloperidol or saline was administered to rats daily for 1, 8, 15 or 22 days. During haloperidol, but not saline administration, changes in plasma homovanillic acid (HVA) concentrations were correlated with changes in nucleus accumbens HVA. Haloperidol administration also had a significant effect on the intercorrelation of dopamine (DA) concentrations and indices of DA turnover across multiple brain areas. In particular, intercorrelations of HVA concentrations among DA terminal brain areas (i.e. striatum, nucleus accumbens, and olfactory tubercle) occurred only during haloperidol treatment.

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U2 - 10.1016/0024-3205(90)90076-4

DO - 10.1016/0024-3205(90)90076-4

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AN - SCOPUS:0025217362

SN - 0024-3205

VL - 46

SP - 707

EP - 713

JO - Life Sciences

JF - Life Sciences

IS - 10

ER -

Interrelationships between plasma homovanillic acid and indices of dopamine turnover in multiple brain areas during haloperidol and saline administration

Abstract

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