Interrogating Adaptive Immunity Using LCMV

Tanushree Dangi; Young Rock Chung; Nicole Palacio; Pablo Penaloza-MacMaster

doi:10.1002/cpim.99

Interrogating Adaptive Immunity Using LCMV

Tanushree Dangi, Young Rock Chung, Nicole Palacio, Pablo Penaloza-MacMaster^*

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

In this invited article, we explain technical aspects of the lymphocytic choriomeningitis virus (LCMV) system, providing an update of a prior contribution by Matthias von Herrath and J. Lindsay Whitton. We provide an explanation of the LCMV infection models, highlighting the importance of selecting an appropriate route and viral strain. We also describe how to quantify virus-specific immune responses, followed by an explanation of useful transgenic systems. Specifically, our article will focus on the following protocols.

Original language	English (US)
Article number	e99
Journal	Current Protocols in Immunology
Volume	130
Issue number	1
DOIs	https://doi.org/10.1002/cpim.99
State	Published - Sep 1 2020

Keywords

LCMV model
acute viral infection
chronic viral infection
immune exhaustion
immune memory

ASJC Scopus subject areas

Immunology

Access to Document

10.1002/cpim.99

Cite this

@article{5c9befe7e6bb48b08bda257386f9dedb,

title = "Interrogating Adaptive Immunity Using LCMV",

abstract = "In this invited article, we explain technical aspects of the lymphocytic choriomeningitis virus (LCMV) system, providing an update of a prior contribution by Matthias von Herrath and J. Lindsay Whitton. We provide an explanation of the LCMV infection models, highlighting the importance of selecting an appropriate route and viral strain. We also describe how to quantify virus-specific immune responses, followed by an explanation of useful transgenic systems. Specifically, our article will focus on the following protocols.",

keywords = "LCMV model, acute viral infection, chronic viral infection, immune exhaustion, immune memory",

author = "Tanushree Dangi and Chung, {Young Rock} and Nicole Palacio and Pablo Penaloza-MacMaster",

note = "Funding Information: These studies were funded by a grant from the National Institutes of Health (1R21AI132848‐01A1) to P.P.M. Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC",

year = "2020",

month = sep,

day = "1",

doi = "10.1002/cpim.99",

language = "English (US)",

volume = "130",

journal = "Current Protocols in Immunology",

issn = "1934-3671",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Interrogating Adaptive Immunity Using LCMV

AU - Dangi, Tanushree

AU - Chung, Young Rock

AU - Palacio, Nicole

AU - Penaloza-MacMaster, Pablo

PY - 2020/9/1

Y1 - 2020/9/1

N2 - In this invited article, we explain technical aspects of the lymphocytic choriomeningitis virus (LCMV) system, providing an update of a prior contribution by Matthias von Herrath and J. Lindsay Whitton. We provide an explanation of the LCMV infection models, highlighting the importance of selecting an appropriate route and viral strain. We also describe how to quantify virus-specific immune responses, followed by an explanation of useful transgenic systems. Specifically, our article will focus on the following protocols.

AB - In this invited article, we explain technical aspects of the lymphocytic choriomeningitis virus (LCMV) system, providing an update of a prior contribution by Matthias von Herrath and J. Lindsay Whitton. We provide an explanation of the LCMV infection models, highlighting the importance of selecting an appropriate route and viral strain. We also describe how to quantify virus-specific immune responses, followed by an explanation of useful transgenic systems. Specifically, our article will focus on the following protocols.

KW - LCMV model

KW - acute viral infection

KW - chronic viral infection

KW - immune exhaustion

KW - immune memory

UR - http://www.scopus.com/inward/record.url?scp=85090943271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85090943271&partnerID=8YFLogxK

U2 - 10.1002/cpim.99

DO - 10.1002/cpim.99

M3 - Article

C2 - 32940427

AN - SCOPUS:85090943271

SN - 1934-3671

VL - 130

JO - Current Protocols in Immunology

JF - Current Protocols in Immunology

IS - 1

M1 - e99

ER -

Interrogating Adaptive Immunity Using LCMV

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this