Interrogating Adaptive Immunity Using LCMV

Tanushree Dangi, Young Rock Chung, Nicole Palacio, Pablo Penaloza-MacMaster*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In this invited article, we explain technical aspects of the lymphocytic choriomeningitis virus (LCMV) system, providing an update of a prior contribution by Matthias von Herrath and J. Lindsay Whitton. We provide an explanation of the LCMV infection models, highlighting the importance of selecting an appropriate route and viral strain. We also describe how to quantify virus-specific immune responses, followed by an explanation of useful transgenic systems. Specifically, our article will focus on the following protocols.

Original languageEnglish (US)
Article numbere99
JournalCurrent Protocols in Immunology
Volume130
Issue number1
DOIs
StatePublished - Sep 1 2020

Keywords

  • LCMV model
  • acute viral infection
  • chronic viral infection
  • immune exhaustion
  • immune memory

ASJC Scopus subject areas

  • Immunology

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