Abstract
In this invited article, we explain technical aspects of the lymphocytic choriomeningitis virus (LCMV) system, providing an update of a prior contribution by Matthias von Herrath and J. Lindsay Whitton. We provide an explanation of the LCMV infection models, highlighting the importance of selecting an appropriate route and viral strain. We also describe how to quantify virus-specific immune responses, followed by an explanation of useful transgenic systems. Specifically, our article will focus on the following protocols.
| Original language | English (US) |
|---|---|
| Article number | e99 |
| Journal | Current Protocols in Immunology |
| Volume | 130 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 1 2020 |
Funding
These studies were funded by a grant from the National Institutes of Health (1R21AI132848‐01A1) to P.P.M.
Keywords
- LCMV model
- acute viral infection
- chronic viral infection
- immune exhaustion
- immune memory
ASJC Scopus subject areas
- Immunology