Interrogating Circulating Microsomes and Exosomes Using Metal Nanoparticles

Yi Ge Zhou, Reza M. Mohamadi, Mahla Poudineh, Leyla Kermanshah, Sharif Ahmed, Tina Saberi Safaei, Jessica Stojcic, Robert K. Nam, Edward H. Sargent, Shana O. Kelley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

130 Scopus citations


A chip-based approach for electrochemical characterization and detection of microsomes and exosomes based on direct electro-oxidation of metal nanoparticles (MNPs) that specifically recognize surface markers of these vesicles is reported. It is found that exosomes and microsomes derived from prostate cancer cells can be identified by their surface proteins EpCAM and PSMA, suggesting the potential of exosomes and microsomes for use as diagnostic biomarkers.

Original languageEnglish (US)
Pages (from-to)727-732
Number of pages6
Issue number6
StatePublished - Feb 10 2016


  • electrochemistry
  • exosomes
  • microsomes
  • nanoparticles
  • prostate cancer

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)


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