Interrogating genomic and epigenomic data to understand prostate cancer

Jung Kim, Jindan Yu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Major breakthroughs at the beginning of this century in high-throughput technologies have profoundly transformed biological research. Significant knowledge has been gained regarding our biological system and its disease such as malignant transformation. In this review, we summarize leading discoveries in prostate cancer research derived from the use of high-throughput approaches powered by microarrays and massively parallel next-generation sequencing (NGS). These include the seminal discovery of chromosomal translocations such as TMPRSS2-ERG gene fusions as well as the identification of critical oncogenes exemplified by the polycomb group protein EZH2. We then demonstrate the power of interrogating genomic and epigenomic data in understanding the plethora of mechanisms of transcriptional regulation. As an example, we review how androgen receptor (AR) binding events are mediated at multiple levels through protein-DNA interaction, histone and DNA modifications, as well as high-order chromatin structural changes.

Original languageEnglish (US)
Pages (from-to)186-196
Number of pages11
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1825
Issue number2
DOIs
StatePublished - Apr 2012

Keywords

  • Androgen receptor
  • EZH2
  • FoxA1
  • Gene fusion
  • Integrative genomics
  • Nucleosome positioning
  • Transcriptional regulation

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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