Interrogating Metabolism in Brain Cancer

Travis C. Salzillo, Jingzhe Hu, Linda Nguyen, Nicholas Whiting, Jaehyuk Lee, Joseph Weygand, Prasanta Dutta, Shivanand Pudakalakatti, Niki Zacharias Millward, Seth T. Gammon, Frederick F. Lang, Amy B. Heimberger, Pratip K. Bhattacharya*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnetic resonance spectroscopy to the promising hyperpolarized metabolic imaging and chemical exchange saturation transfer and emerging techniques of imaging inflammation. Some of these techniques are at an early stage of development and clinical trials are in progress in patients to establish the clinical efficacy. It is likely that in vivo metabolomics and metabolic imaging is the next frontier in brain cancer diagnosis and assessing therapeutic efficacy; with the combined knowledge of genomics and proteomics a complete understanding of tumorigenesis in brain might be achieved.

Original languageEnglish (US)
Pages (from-to)687-703
Number of pages17
JournalMagnetic Resonance Imaging Clinics of North America
Volume24
Issue number4
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Keywords

  • CEST
  • DNP
  • GC/MS
  • Hyperpolarization
  • Metabolic imaging
  • MRI
  • MRS
  • NMR

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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