Intersection of mTOR and STAT signaling in immunity

Diana Saleiro, Leonidas C. Platanias*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations

Abstract

Optimal regulation of immune networks is essential for the generation of effective immune responses, and defects in such networks can lead to immunodeficiency while uncontrolled responses can result in autoimmune disorders. mTOR and STAT signaling cascades are key regulators of the differentiation and function of cells of the immune system. Both pathways act as sensors and transducers of environmental stimuli, and recent evidence has revealed points of crosstalk between these pathways, highlighting synergistic regulation of immune cell differentiation and function. We review here the current understanding of mTOR and STAT interactions in T cells and innate immune cells, and discuss potential mechanisms underlying these events. We further outline models for the intersection of these pathways in the regulation of immunity and highlight important areas for future research.

Original languageEnglish (US)
Pages (from-to)21-29
Number of pages9
JournalTrends in Immunology
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Immunity
  • MTOR
  • STAT
  • Signaling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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