@article{87a0ad3ee2cd495da40b5ac1a0776a03,
title = "Intestinal microbiota-produced trimethylamine-N-oxide and its association with coronary stenosis and HIV serostatus",
abstract = "Recent evidence has shown a complex relationship between the gut microbiota, dietary nutrients, and cardiovascular disease (CVD). Trimethylamine-N-oxide (TMAO) production, initiated by the microbiota, has been associated with CVD events. We sought to test if this association exists in HIV-infected persons. After adjusting for aspirin use and CVD risk factors, HIV-infected men were more likely to have coronary stenosis in the second and third TMAO quartiles compared with the first quartile, but did not differ significantly in the fourth quartile. We found an inverted U-shaped association between TMAO levels and the presence of coronary artery stenosis among HIV-infected men.",
keywords = "Coronary artery disease, HIV, Trimethylamine-N-oxide",
author = "{Elliott Miller}, P. and Haberlen, {Sabina A.} and Brown, {Todd T.} and Margolick, {Joseph B.} and DiDonato, {Joseph A.} and Hazen, {Stanley L.} and Witt, {Mallory D.} and Kingsley, {Lawrence A.} and Palella, {Frank J.} and Matthew Budoff and Jacobson, {Lisa P.} and Post, {Wendy S.} and Sears, {Cynthia L.}",
note = "Funding Information: The MACS CVD study is funded by NHLBI: RO1 HL095129 (Post). The TMAO study is funded by a subaward to C.L.S. through NIAID P30AI094189 (Chaisson). Data in this article were collected by the MACS with centers (Principal Investigators) at: Johns Hopkins University Bloomberg School of Public Health (J.B.M.), U01-AI35042; Northwestern University (Steven Wolinsky), U01-AI35039; University of California, Los Angeles (Roger Detels), U01-AI35040; University of Pittsburgh (Charles Rinaldo), U01-AI35041; the Center for Analysis and Management of MACS, Johns Hopkins University Bloomberg School of Public Health (L.P.J.), UM1-AI35043. The MACS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the National Cancer Institute (NCI). MACS data collection is also supported by UL1 TR 001079 (JHU CTSA). Website located at http://www.statepi.jhsph.edu/macs/macs.html. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} Copyright 2015 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2016",
month = may,
day = "1",
doi = "10.1097/QAI.0000000000000937",
language = "English (US)",
volume = "72",
pages = "114--118",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "1",
}
