Intra-articular Hyaluronan Therapy for Symptomatic Knee Osteoarthritis

Carrie Richardson*, Anna Plaas, Joel A. Block

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Intra-articular hyaluronan therapy (IAHA) is a common but controversial nonsurgical treatment of symptomatic knee osteoarthritis. The overall treatment effect of IAHA for osteoarthritis pain is substantial, but the majority of this benefit is mediated by the placebo effect. Despite the large overall benefit of IAHA when the effect of the hyaluronan is combined with the placebo effect, there is only a small benefit of questionable clinical significance of IAHA compared with intra-articular placebo. Compared with intra-articular corticosteroids, however, IAHA most likely is comparable for long-term pain relief and possibly slightly inferior for short-term pain relief.

Original languageEnglish (US)
Pages (from-to)439-451
Number of pages13
JournalRheumatic Disease Clinics of North America
Issue number3
StatePublished - Aug 2019


  • Corticosteroids
  • Hyaluronan
  • Intra-articular
  • Knee osteoarthritis
  • Pain

ASJC Scopus subject areas

  • Rheumatology


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