Intra-articular Morphine and Clonidine Injection after HipArthroscopy:A Randomized,Triple-Blind ControlledTrial

C. J. Cogan*, V. K. Tjong, K. F. Dunne, S. Sahota, J. Tuttle, M. A. Terry

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Hip arthroscopy is an increasingly common outpatient procedure for which postoperative pain control remains a vital component of patient care and surgical outcome.The objective of this study was to determine the effect of intra-articular morphine and clonidine injection as compared with placebo on postoperative opioid requirement after hip arthroscopy. Seventy patients undergoing primary hip arthroscopy were randomized to receive an 11mL intra-articular injection of 10mg morphine + 100mcg clonidine (study) or normal saline (control) at the conclusion of arthroscopy.The primary outcome was opioid consumption during recovery in the post-anesthesia care unit (PACU). Mean PACU opioid consumption in oral morphine equivalents (mEq) in the study group was 37.0 [95% CI: 28.8-45.3] compared to 40.1 [95% CI: 31.8-48.4] in the control group (P=0.29).With the numbers available, intraoperative intra-articular morphine and clonidine injection showed no statistically significant difference in PACU postoperative opioid consumption compared to normal saline control after hip arthroscopy.

Original languageEnglish (US)
Pages (from-to)5-9
Number of pages5
JournalAmbulatory Surgery
Issue number1
StatePublished - Mar 2020


  • Clonidine
  • Hip arthroscopy
  • Intra-articular injection
  • Morphine
  • Opioid consumption

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical
  • Anesthesiology and Pain Medicine


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