Intra-individual and inter-individual variations in sperm aneuploidy frequencies in normal men

Helen G. Tempest, Evelyn Ko, Alfred W Rademaker, Peter Chan, Bernard Robaire, Renée H. Martin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Objective: To investigate whether there are intra-individual and/or inter-individual variations in sperm aneuploidy frequencies within the normal male population, and, if this is the case, whether they are sporadic or time-stable variants. Design: Prospective study. Setting: University research laboratory. Patient(s): Ten men aged 18-32 years. Intervention(s): None. Main Outcome Measure(s): Fluorescence in situ hybridization was used to investigate sperm aneuploidy frequencies for chromosomes X, Y, 13, and 21 in serial semen samples collected over a period of 12-18 months. Result(s): Intra-individual and inter-individual variations were investigated by comparing serial samples from the same donor and by comparing the donors with each other, respectively. Intra-individual variations were found in all 10 donors for at least one investigated chromosome; variations tended to be sporadic events affecting only one time point. Inter-individual variations were found for all chromosomes (except XX and YY disomy and disomy 21), with three men identified as stable variants, consistently producing higher levels of aneuploidy for at least one of the following aneuploidies: sex chromosome nullisomy; disomy 13, or diploidy. Conclusion(s): These results suggest that there are a number of factors and mechanisms that have the potential to sporadically or consistently affect sperm aneuploidy.

Original languageEnglish (US)
Pages (from-to)185-192
Number of pages8
JournalFertility and Sterility
Volume91
Issue number1
DOIs
StatePublished - Jan 1 2009

Keywords

  • FISH
  • Sperm aneuploidy
  • inter-individual variation
  • intra-individual variation
  • nondisjunction

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Fingerprint Dive into the research topics of 'Intra-individual and inter-individual variations in sperm aneuploidy frequencies in normal men'. Together they form a unique fingerprint.

Cite this