Intracardiac thrombus formation and pulmonary thromboembolism immediately after graft reperfusion in 7 patients undergoing liver transplantation

Edward Gologorsky, Andre M. De Wolf, Victor Scott, Shushma Aggarwal, Michael Dishart, Yoogoo Kang

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

Intravascular and/or intracardiac thrombus formation followed by pulmonary thromboembolism with right ventricular dysfunction immediately after graft reperfusion during orthotopic liver transplantation (OLT) is described in 7 patients. This complication may have been related to excessive activation of the coagulation system by graft reperfusion, which overwhelmed anticoagulation mechanisms and was disproportionate to fibrinolysis. Activation of the coagulation system may be more pronounced in patients who receive less than optimal grafts, require massive transfusion, or have septic complications at the time of OLT. It is unclear whether antifibrinolytic therapy during the anhepatic stage had a role. Transesophageal echocardiography was useful in diagnosing and managing intracardiac thrombus and pulmonary thromboembolism.

Original languageEnglish (US)
Pages (from-to)783-789
Number of pages7
JournalLiver Transplantation
Volume7
Issue number9
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

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