Intracellular calcium does not directly modulate cardiac pacemaker (if) channels

A. Zaza; G. Maccaferri; M. Mangoni; D. DiFrancesco

doi:10.1007/BF00370312

Intracellular calcium does not directly modulate cardiac pacemaker (i_f) channels

A. Zaza, G. Maccaferri, M. Mangoni, D. DiFrancesco^*

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A study on the cardiac pacemaker current if in inside-out macro-patches of sino-atrial (SA) node cells has recently demonstrated that i_f channels are directly activated by intracellular cAMP [4]. Using the same preparation, here we investigate the possibility that internal Ca²⁺ ions play a role in the modulation of i_f channels. Our results indicate that Ca²⁺ ions do not have a direct activating effect on i_f.

Original language	English (US)
Pages (from-to)	662-664
Number of pages	3
Journal	Pflügers Archiv European Journal of Physiology
Volume	419
Issue number	6
DOIs	https://doi.org/10.1007/BF00370312
State	Published - Dec 1 1991

ASJC Scopus subject areas

Physiology
Clinical Biochemistry
Physiology (medical)

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abstract = "A study on the cardiac pacemaker current if in inside-out macro-patches of sino-atrial (SA) node cells has recently demonstrated that if channels are directly activated by intracellular cAMP [4]. Using the same preparation, here we investigate the possibility that internal Ca2+ ions play a role in the modulation of if channels. Our results indicate that Ca2+ ions do not have a direct activating effect on if.",

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AU - DiFrancesco, D.

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AB - A study on the cardiac pacemaker current if in inside-out macro-patches of sino-atrial (SA) node cells has recently demonstrated that if channels are directly activated by intracellular cAMP [4]. Using the same preparation, here we investigate the possibility that internal Ca2+ ions play a role in the modulation of if channels. Our results indicate that Ca2+ ions do not have a direct activating effect on if.

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Intracellular calcium does not directly modulate cardiac pacemaker (i_f) channels

Abstract

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