Intracellular calcium does not directly modulate cardiac pacemaker (if) channels

A. Zaza, G. Maccaferri, M. Mangoni, D. DiFrancesco*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A study on the cardiac pacemaker current if in inside-out macro-patches of sino-atrial (SA) node cells has recently demonstrated that if channels are directly activated by intracellular cAMP [4]. Using the same preparation, here we investigate the possibility that internal Ca2+ ions play a role in the modulation of if channels. Our results indicate that Ca2+ ions do not have a direct activating effect on if.

Original languageEnglish (US)
Pages (from-to)662-664
Number of pages3
JournalPflügers Archiv European Journal of Physiology
Issue number6
StatePublished - Dec 1 1991

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)


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