Intracellular hyaluronan: A new frontier for inflammation?

Vincent C. Hascall*, Alana K. Majors, Carol A. De La Motte, Stephen P. Evanko, Aimin Wang, Judith A. Drazba, Scott A. Strong, Thomas N. Wight

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

235 Scopus citations


A variety of obstacles have hindered the ultrastructural localization of hyaluronan (HA). These include a lack of adequate fixation techniques to prevent the loss of HA, the lack of highly sensitive and specific probes, and a lack of accessibility due to the masking of HA by HA-binding macromolecules such as proteoglycans and glycoproteins. Despite these problems, a number of studies, both biochemical and histochemical, have been published indicating that HA is not restricted to the extracellular milieu, but is also present intracellularly. This review focuses on the possible functions of intracellular HA, its potential relationships to extracellular HA structures, and implications for inflammatory processes.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalBiochimica et Biophysica Acta - General Subjects
Issue number1-2
StatePublished - Jul 6 2004


  • Glycoprotein
  • Hyaluronan
  • Proteoglycan

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology


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