Intracellular levels of SGP-2 (Clusterin) correlate with tumor grade in prostate cancer

Joseph Steinberg, Ryoichi Oyasu, Sharon Lang, Sharon Sintich, Alfred Rademaker, Chung Lee, James M. Kozlowski, Julia A. Sensibar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

186 Scopus citations

Abstract

Our previous observations in LNCaP cells in vitro demonstrated an association between apoptotic cell death resistance and SGP-2 (Clusterin) overexpression. Accordingly, we hypothesized that high levels of cellular SGP-2 would aid in identifying biologically aggressive prostate cancer cells with unique survival advantages. To test this hypothesis, 40 archival radical prostatectomy and/or biopsy specimens of varying grades of prostate cancer were subjected to immunohistochemical SGP-2 staining. The resulting epithelial stains were quantified subjectively on a scale of 1-3 by four independent observers. Benign prostatic epithelial cells from young donors served as controls and showed a consistently weak staining intensity. In contrast, prostate cancer specimens showed varying degrees of staining intensity that correlated with a Gleason pattern (P = 0.006). This correlation supports the hypothesis that protection from apoptotic death may account, in part, for biologically aggressive tumor behavior.

Original languageEnglish (US)
Pages (from-to)1707-1711
Number of pages5
JournalClinical Cancer Research
Volume3
Issue number10
StatePublished - Oct 1997

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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