Intracellular organelles in the saga of Ca 2+ homeostasis: Different molecules for different purposes?

Enrico Zampese, Paola Pizzo*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


An increase in the concentration of cytosolic free Ca 2+ is a key component regulating different cellular processes ranging from egg fertilization, active secretion and movement, to cell differentiation and death. The multitude of phenomena modulated by Ca 2+, however, do not simply rely on increases/decreases in its concentration, but also on specific timing, shape and sub-cellular localization of its signals that, combined together, provide a huge versatility in Ca 2+ signaling. Intracellular organelles and their Ca 2+ handling machineries exert key roles in this complex and precise mechanism, and this review will try to depict a map of Ca 2+ routes inside cells, highlighting the uniqueness of the different Ca 2+ toolkit components and the complexity of the interactions between them.

Original languageEnglish (US)
Pages (from-to)1077-1104
Number of pages28
JournalCellular and Molecular Life Sciences
Issue number7
StatePublished - Apr 2012


  • Ca Microdomains
  • Ca pumps
  • Ca releasing channels
  • Ca stores
  • Mitochondria
  • Sub-cellular signaling

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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