Intracellular recordings from canine intracardiac ganglion cells

Xiaohe Xi, John X. Thomas, Walter C. Randall, Robert D. Wurster*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Stable transmembrane potentials were recorded from 60 canine intracardiac ganglion cells taken from 10 dogs, which had intact synaptic connections: mean resting membrane potential, input resistance and time constant were 61.5 mV, 70 MΩ and 3.3 ms. Action potentials could be evoked by intrasomal current injection and by orthodromic and antidromic stimulation of interganglionic nerves. Orthodromic action potentials were initiated by excitatory postsynaptic potentials and mediated by nicotinic receptors. All action potentials could be blocked by tetrodotoxin. Intracellular labeling revealed large cell bodies and long dendritic and axonal processes. Thus, the functional and anatomical properties of canine cardiac ganglion cells and their synaptic connections can be elucidated using this preparation.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalJournal of the Autonomic Nervous System
Volume32
Issue number2
DOIs
StatePublished - Feb 1991

Keywords

  • Autonomic ganglion
  • Cardiac control
  • Intracardiac ganglion cell
  • Vagus nerve

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology

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