Intracorporeal bioreactor with immobilized phospholipase A 2 to reduce plasma cholesterol

S. Shefer*, V. Rosenberger, J. Wertheim, R. Langer

*Corresponding author for this work

Research output: Contribution to journalConference article

Abstract

The effect of phospholipase A 2 (PLA 2 )-filled bioreactor on the cholesterol level of hypercholesterolemic New Zealand white rabbits was characterized. Bioreactors were constructed by immobilizing the enzyme to beads with amino residues and packing the beads with the enzyme into the hollow fiber. Enzymatic activity was monitored by titrating the reaction between PLA 2 and the substrate L-alpha-phosphatideylcholine dipalmitoyl with sodium hydroxide.

Original languageEnglish (US)
Pages (from-to)A56
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number5
StatePublished - Nov 1 1994
EventProceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA
Duration: Jul 24 1994Jul 27 1994

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

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