Intracranial malignancies occurring more than 20 years after radiation therapy for pituitary adenoma

Wen Ying Wu-Chen, Dina A. Jacobs, Nicholas J. Volpe, Joseph O. Dalmau, Mark L. Moster

Research output: Contribution to journalArticle

19 Scopus citations


A 37-year-old woman developed a left third cranial nerve palsy 28 years after radiation for a nonsecreting pituitary adenoma. Imaging disclosed a left parasellar mass and a midbrain/pontine signal abnormality. Biopsy of the parasellar mass revealed a malignant sarcoma. The brainstem abnormality was presumptively diagnosed as a malignant glioma. A 63-year-old man developed a malignant astrocytoma of the left optic nerve and chiasm 23 years after partial excision and radiation of a nonsecreting pituitary adenoma. Both patients died of their malignancies. Although secondary malignancies have been described in this setting, such long latencies have not been reported.

Original languageEnglish (US)
Pages (from-to)289-295
Number of pages7
JournalJournal of Neuro-Ophthalmology
Issue number4
StatePublished - Dec 1 2009


ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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