Intracranial recordings and human memory

Elizabeth L. Johnson*, Robert T. Knight

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


Recent work involving intracranial recording during human memory performance provides superb spatiotemporal resolution on mnemonic processes. These data demonstrate that the cortical regions identified in neuroimaging studies of memory fall into temporally distinct networks and the hippocampal theta activity reported in animal memory literature also plays a central role in human memory. Memory is linked to activity at multiple interacting frequencies, ranging from 1 to 500. Hz. High-frequency responses and coupling between different frequencies suggest that frontal cortex activity is critical to human memory processes, as well as a potential key role for the thalamus in neocortical oscillations. Future research will inform unresolved questions in the neuroscience of human memory and guide creation of stimulation protocols to facilitate function in the damaged brain.

Original languageEnglish (US)
Pages (from-to)18-25
Number of pages8
JournalCurrent opinion in neurobiology
StatePublished - Apr 2015

ASJC Scopus subject areas

  • Neuroscience(all)


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