Intradermal injection, as opposed to subcutaneous injection, enhances immunogenicity and suppresses tumorigenicity of tumor cells

Bernard Bonnotte, Michael Gough, Vy Phan, Atique Ahmed, Heung Chong, François Martin, Richard G. Vile*

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Tumor cell immunogenicity depends heavily upon the microenvironment in which the cells grow. We have compared the tumorigenicity and immunogenicity of the same tumor cells when injected either into the dermis, a tissue containing numerous dendritic cells (DCs), or s.c., at a site which contains only few DCs. After s.c. injection, progressive tumors were constantly obtained, whereas most intradermal injections did not give rise to tumor and immunized animals against additional challenge. We present evidence that the high density of DCs at dermal sites facilitates the capture of tumor antigens and that local inflammation induces maturation of the DCs and their migration into draining lymph nodes.

Original languageEnglish (US)
Pages (from-to)2145-2149
Number of pages5
JournalCancer Research
Volume63
Issue number9
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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