Abstract
Bleomycin is a cytotoxic antibiotic that has a sclerosing effect on vascular endothelium. Small doses can be injected locally to reduce the size of various vascular malformations. Recognition that targeted intralesional injection carries the potential to cause hyperpigmentation, specifically in areas of skin trauma, and has led our department to implement a bleomycin skin-protective protocol. On review of cases performed following protocol implementation, no patients developed hyperpigmentation attributable to iatrogenic skin trauma. We present our bleomycin skin protection protocol to guide peer institutions in the initiation of similar quality improvement initiatives.
| Original language | English (US) |
|---|---|
| Pages (from-to) | e01551 |
| Journal | A&A practice |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 5 2022 |
Funding
We are grateful to Gilles Lambaré for providing the Marmousi-based data. The authors thank Biondo Biondi for many useful conversations. We thank the associate editor and referee William Schneider for very helpful comments and criticisms that resulted in a much-improved presentation. The work reported here was partly supported by The Rice Inversion Project. The first author also acknowledges the support of the Mathematical Sciences Research Institute, through NSF grant DMS-9810361.
ASJC Scopus subject areas
- General Medicine