Intraocular pressure and glycosaminoglycan distribution in the rabbit eye: Effect of age and dexamethasone

P. A. Knepper, M. Breen, H. G. Weinstein*, L. J. Blacik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

The effect of dexamethasone on intraocular pressure was studied in young and old rabbits and was related to the concentration and distribution of the glycosaminoglycans obtained from the proteoglycan in the anterior segment of the eye (central cornea, peripheral cornea, sclera and iris). Topical application of dexamethasone resulted in an increase of intraocular pressure of young rabbits but had no effect on the intraocular pressure of old rabbits. The changes in the relative distribution of the glycosaminoglycans components were observed as a function of age and/or dexamethasone treatment. The ratio of non-uronic acid containing glycosaminoglycans (keratan sulfate) to the uronic acid containing glycosaminoglycans decreased with age and was reversed by dexamethasone treatment of the aged animal. Thus, the distribution of the glycosaminoglycans induced by dexamethasone treatment may modulate intraocular pressure.

Original languageEnglish (US)
Pages (from-to)567-575
Number of pages9
JournalExperimental eye research
Volume27
Issue number5
DOIs
StatePublished - Nov 1978

Keywords

  • age
  • chondroitin sulfate
  • dexamethasone
  • eye
  • glycosaminoglycans
  • intraocular pressure
  • keratan sulfate
  • rabbit
  • uronic acid

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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