Intraoperative Blood Loss and Prognosis in Prostate Cancer Patients Undergoing Radical Retropubic Prostatectomy

Michael G. Oefelein, Laura A. Colangelo, Alfred W Rademaker, Kevin T. McVary*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Purpose: To assess more thoroughly the prognostic significance of perioperative transfusions, we examined a previously ignored factor, namely intraoperative blood loss. Materials and Methods: Univariate and multivariate stepwise regression analysis was performed on results of a 10-year series of 251 consecutive men who underwent radical retropubic prostatectomy for clinically localized carcinoma. Results: Gleason score, operative blood loss and pathological stage were significantly (p less than 0.0001) associated with progression-free survival. A risk ratio of 1.08 (95 percent confidence interval 1.05 to 1.10) was demonstrated for every 100 ml. of operative blood loss. Conclusions: The operative blood loss but not the type (autologous or allogeneic) of blood transfused was significantly related to decreased recurrence-free survival after radical retropubic prostatectomy. This finding implies that the operative events necessitating transfusion are potentially more significant than the immunological effects of the transfusion.

Original languageEnglish (US)
Pages (from-to)442-447
Number of pages6
JournalThe Journal of Urology
Issue number2
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Urology


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