Intraoperative radiation "Boost" to the surgical resection bed following pancreaticoduodenectomy for a borderline resectable pancreatic carcinoma: A case report

Tarita O. Thomas*, William Small, Mark Fleming, Song Kang, Richard A. Hoefer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Neoadjuvant therapy including chemotherapy alone or concurrent chemotherapy with external bream radiation is a standard treatment strategy for borderline resectable pancreatic adenocarcinoma and is also used routinely for primary operable cancers at some institutions (1). The use of intraoperative radiation therapy (IORT) has been limited largely because of the logistical issues in delivery of radiation during surgery (2). This is the first reported case of a borderline resectable pancreas cancer patient who underwent neoadjuvant chemo-radiation therapy followed by resection with the use of IORT using the mobile IntraBeam device to boost the resection bed and improve local control by dose escalation.

Original languageEnglish (US)
Article number12
JournalFrontiers in Oncology
Volume8
Issue numberMAR
DOIs
StatePublished - Mar 23 2018
Externally publishedYes

Keywords

  • Borderline resectable
  • IORT
  • Intraoperative radiation therapy
  • Neoadjuvant therapy
  • Pancreas cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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