Intrathecal baclofen: Effects on nocturnal leg muscle spasticity

H. M. Kravitz; D. M. Corcos; G. Hansen; R. D. Penn; R. D. Cartwright; J. Gianino

doi:10.1097/00002060-199202000-00012

Intrathecal baclofen: Effects on nocturnal leg muscle spasticity

H. M. Kravitz, D. M. Corcos^*, G. Hansen, R. D. Penn, R. D. Cartwright, J. Gianino

^*Corresponding author for this work

Physical Therapy and Human Movement Sciences

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Electromyographic activity was recorded from tibialis anterior during nocturnal polysomnography in six patients with severe spasticity of spinal origin. The patients had a baclofen reservoir system implanted subcutaneously into their lumbar subarachnoid space and were studied for two nights in a double-blind, placebo controlled, crossover design. Tibialis anterior electromyographic activity per hour of sleep was reduced on the night of baclofen infusion. In particular, less electromyographic activity occurred after arousal from sleep.

Original language	English (US)
Pages (from-to)	48-52
Number of pages	5
Journal	American Journal of Physical Medicine and Rehabilitation
Volume	71
Issue number	1
DOIs	https://doi.org/10.1097/00002060-199202000-00012
State	Published - 1992

Keywords

Functional Outcome
Multiple Sclerosis
Sleep
Spasticity
Spinal Cord Injuries
Therapy-Computer Assisted

ASJC Scopus subject areas

Physical Therapy, Sports Therapy and Rehabilitation
Rehabilitation

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abstract = "Electromyographic activity was recorded from tibialis anterior during nocturnal polysomnography in six patients with severe spasticity of spinal origin. The patients had a baclofen reservoir system implanted subcutaneously into their lumbar subarachnoid space and were studied for two nights in a double-blind, placebo controlled, crossover design. Tibialis anterior electromyographic activity per hour of sleep was reduced on the night of baclofen infusion. In particular, less electromyographic activity occurred after arousal from sleep.",

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T2 - Effects on nocturnal leg muscle spasticity

AU - Kravitz, H. M.

AU - Corcos, D. M.

AU - Hansen, G.

AU - Penn, R. D.

AU - Cartwright, R. D.

AU - Gianino, J.

PY - 1992

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AB - Electromyographic activity was recorded from tibialis anterior during nocturnal polysomnography in six patients with severe spasticity of spinal origin. The patients had a baclofen reservoir system implanted subcutaneously into their lumbar subarachnoid space and were studied for two nights in a double-blind, placebo controlled, crossover design. Tibialis anterior electromyographic activity per hour of sleep was reduced on the night of baclofen infusion. In particular, less electromyographic activity occurred after arousal from sleep.

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KW - Multiple Sclerosis

KW - Sleep

KW - Spasticity

KW - Spinal Cord Injuries

KW - Therapy-Computer Assisted

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Intrathecal baclofen: Effects on nocturnal leg muscle spasticity

Abstract

Keywords

ASJC Scopus subject areas

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