Intrathecal baclofen: Effects on nocturnal leg muscle spasticity

H. M. Kravitz, D. M. Corcos*, G. Hansen, R. D. Penn, R. D. Cartwright, J. Gianino

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Electromyographic activity was recorded from tibialis anterior during nocturnal polysomnography in six patients with severe spasticity of spinal origin. The patients had a baclofen reservoir system implanted subcutaneously into their lumbar subarachnoid space and were studied for two nights in a double-blind, placebo controlled, crossover design. Tibialis anterior electromyographic activity per hour of sleep was reduced on the night of baclofen infusion. In particular, less electromyographic activity occurred after arousal from sleep.

Original languageEnglish (US)
Pages (from-to)48-52
Number of pages5
JournalAmerican Journal of Physical Medicine and Rehabilitation
Issue number1
StatePublished - 1992


  • Functional Outcome
  • Multiple Sclerosis
  • Sleep
  • Spasticity
  • Spinal Cord Injuries
  • Therapy-Computer Assisted

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation


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