Intrauterine inseminations with washed human spermatozoa

E. Confino, J. Friberg, A. B. Dudkiewicz, N. Gleicher

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The success of intrauterine inseminations with washed human spermatozoa was evaluated in four groups of patients. The first two groups were couples in whom either the man or the woman had detectable circulating sperm-agglutinating antibodies. The third group included couples where the woman exhibited hostile or absent cervical mucus, whereas the fourth group represented couples with oligozoospermic males. The couples underwent 3.7 ± 2.1 insemination cycles, with a 30% overall pregnancy rate for all four groups. Intrauterine inseminations of women with hostile cervical mucus yielded a 68% conception rate. Couples with either male or female serum sperm-agglutinating antibodies showed 25% of 40% pregnancy rates, respectively. However, none of the couples with oligozoospermic males achieved pregnancy. Intrauterine inseminations with washed human spermatozoa thus represent a satisfactory method of achieving pregnancy in women with hostile cervical mucus and in couples with circulating sperm agglutinating antibodies. Couples in whom oliogozoospermia has been identified as the principal cause of infertility do not seem to benefit from this therapy.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalFertility and Sterility
Volume46
Issue number1
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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