Intravascular mixing and drug distribution: The concurrent disposition of thiopental and indocyanine green

Thomas K. Henthorn*, Michael J Avram, Tom C Krejcie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The dispositions of concomitantly administered indocyanine green (ICG) and thiopental were determined in 12 patients undergoing general anesthesia and surgery. These were best characterized by a two-compartment ICG model and a four-compartment thiopental model, chiefly because of data obtained from frequent early arterial blood samples. The models had a common central volume (VI), and the peripheral ICG compartment was the subset of a peripheral thiopental compartment. The two-compartment ICG model described its mixing within the intravascular space. The traditional Vc of three-compartment models of thiopental disposition is described by the present four-compartment model as an initial distribution volume, Vl, codetermined by ICG as central blood volume, and a rapidly equilibrating peripheral volume, V4. The combined simultaneous ICG-thiopental model more clearly reflects physiology than do the results of earlier curve-fitting techniques and may be useful in studying the pharmacokinetic basis of altered reactivity to thiopental.

Original languageEnglish (US)
Pages (from-to)56-65
Number of pages10
JournalClinical Pharmacology and Therapeutics
Volume45
Issue number1
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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