Intravenous etidronate in the management of malignant hypercalcemia

E. Ryzen, R. R. Martodam, M. Troxell, A. Benson, A. Paterson, K. Shepard, R. Hicks

Research output: Contribution to journalArticle


The treatment of hypercalcemia remains a common problem in the management of many patients with cancer. We have used intravenously administered etidronate disodium as a therapy for hypercalcemia in 26 patients with malignant disease. Patients with persistent hypercalcemia despite adequate hydration and a serum creatinine level less than or equal to 1.5 mg/dL were allowed on study. Treatment consisted of intravenously administered etidronate disodium at 7.5 mg/kg/day in 250 mL of saline infused over two hours on 1, 2, 3, or 4 consecutive days. The serum calcium level in 19 (73%) of 26 patients returned to the normal range with a mean response time of 3 ± 2 days. Similar response rates were seen in patients with a variety of tumors, including breast cancer, non-small-cell lung cancer, and multiple myeloma. Intravenously administered etidronate appears to be safe and effective therapy for hypercalcemia in patients with malignant disease.

Original languageEnglish (US)
Pages (from-to)449-452
Number of pages4
JournalArchives of Internal Medicine
Issue number3
StatePublished - May 29 1985


ASJC Scopus subject areas

  • Internal Medicine

Cite this

Ryzen, E., Martodam, R. R., Troxell, M., Benson, A., Paterson, A., Shepard, K., & Hicks, R. (1985). Intravenous etidronate in the management of malignant hypercalcemia. Archives of Internal Medicine, 145(3), 449-452.