Intraventricular dyssynchrony assessment using regional contraction from LV motion models

Avan Suinesiaputra, Brett R. Cowan, David A. Bluemke, Pau Medrano-Gracia, Daniel C. Lee, Jõao A C Lima, Alistair A. Young

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

A spatiotemporal 3D left ventricular (LV) motion model was developed to extract regional function for intra left ventricular dyssynchrony (intra-LVD). A finite element model was divided into the standard 17 segments. Temporal interpolation was performed by using periodic control theoretic smoothing splines. Intra-LVD was assessed in terms of systolic dyssynchrony index (SDI) by measuring the dispersion of time to reach peak regional ejection fraction (TPREF). We compared two patient groups: 300 asymptomatic (A: 139M/161F, mean age: 61±9.7 yrs) and 105 patients with myocardial infarction (P: 81M/24F, mean age: 63±10.2 yrs). Consistent regional variation in TPREF was observed in the A group, with the basal septal segments having later TPREF. Omitting these segments significantly reduced the SDI values in both groups (P < .001), but improved the statistical differences between cohorts (P: 8.46±4.15% vs A: 6.03±2.93% with basal septal segments; P: 7.24±4.08% vs A: 4.22±2.27% without). The mean Mahalanobis distance of the P group to the distribution of the A group was increased from 2.66±4.63% to 4.99±8.26% (P < .001). These results strongly suggest that basal septal regions should be removed from intra-LVD indices, to provide better discrimination between the two cohorts.

Original languageEnglish (US)
Title of host publicationFunctional Imaging and Modeling of the Heart - 7th International Conference, FIMH 2013, Proceedings
Pages458-465
Number of pages8
Volume7945 LNCS
DOIs
StatePublished - Jul 11 2013
Event7th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2013 - London, United Kingdom
Duration: Jun 20 2013Jun 22 2013

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7945 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other7th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2013
Country/TerritoryUnited Kingdom
CityLondon
Period6/20/136/22/13

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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