Abstract
Infections with protozoan and helminthic parasites affect multiple organs in the mammalian host. Imaging pathogens in their natural environment takes a more holistic view on biomedical aspects of parasitic infections. Here, we focus on selected organs of the thoracic and abdominopelvic cavities most commonly affected by parasites. Parasitic infections of these organs are often associated with severe medical complications or have health implications beyond the infected individual. Intravital imaging has provided a more dynamic picture of the host–parasite interplay and contributed not only to our understanding of the various disease pathologies, but has also provided fundamental insight into the biology of the parasites.
| Original language | English (US) |
|---|---|
| Article number | e13201 |
| Journal | Cellular Microbiology |
| Volume | 22 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2020 |
Funding
We thank Prof. Friedrich Frischknecht (University of Heidelberg, Germany) for input on this manuscript and Prof. Volker Heussler (IZB, University of Bern, Switzerland), for input and training (MDN) on the techniques here reviewed. We thank Dr. Gavin Meehan (Wellcome Centre for Integrative Parasitology, Glasgow, UK) for his critical and helpful feedback on this manuscript. We thank Prof. Maike Leberl, Prof. Ute Frevert (NYU, New York, USA), Prof. Volker Heussler (IZB, University of Bern, Switzerland), Dr. Tobias Spielmann (BNITM, Hamburg, Germany), Dr. Joana Tavares (i3S and IBMC, Porto, Portugal), Dr. Rogerio Amino (Institut Pasteur, Paris, France), Prof. P'ng Loke (NYUMC, New York, USA), Prof. Paul Kaye (University of York, UK) and Prof. Nancy Guillen (Institut Pasteur, Paris, France) for allowing us to use of their primary IVM images throughout our review. M.D.N. is funded by Long Term EMBO Post‐doctoral fellowship ALTF 1048‐2016 and Human Frontier Science Programme Post‐doctoral fellowship LT000047/2019‐L. C.P.G. is partially funded by March of Dimes, research grant No #6‐FY15‐191. C.A.N. is funded by EVIMalaR EU network (FP7/2013) and the Novartis Foundation for Medical‐Biomedical Research. We thank Prof. Friedrich Frischknecht (University of Heidelberg, Germany) for input on this manuscript and Prof. Volker Heussler (IZB, University of Bern, Switzerland), for input and training (MDN) on the techniques here reviewed. We thank Dr. Gavin Meehan (Wellcome Centre for Integrative Parasitology, Glasgow, UK) for his critical and helpful feedback on this manuscript. We thank Prof. Maike Leberl, Prof. Ute Frevert (NYU, New York, USA), Prof. Volker Heussler (IZB, University of Bern, Switzerland), Dr. Tobias Spielmann (BNITM, Hamburg, Germany), Dr. Joana Tavares (i3S and IBMC, Porto, Portugal), Dr. Rogerio Amino (Institut Pasteur, Paris, France), Prof. P'ng Loke (NYUMC, New York, USA), Prof. Paul Kaye (University of York, UK) and Prof. Nancy Guillen (Institut Pasteur, Paris, France) for allowing us to use of their primary IVM images throughout our review. M.D.N. is funded by Long Term EMBO Post-doctoral fellowship ALTF 1048-2016 and Human Frontier Science Programme Post-doctoral fellowship LT000047/2019-L. C.P.G. is partially funded by March of Dimes, research grant No #6-FY15-191. C.A.N. is funded by EVIMalaR EU network (FP7/2013) and the Novartis Foundation for Medical-Biomedical Research.
Keywords
- diseases
- imaging
- infection
- intravital
- microscopy
- parasitology
ASJC Scopus subject areas
- Microbiology
- Immunology
- Virology