Intrinsic and extrinsic factors controlling benign prostatic growth

Chung Lee*, James M. Kozlowski, John T. Grayhack

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


This review will present a new concept on the etiology of the development of benign prostatic hyperplasia (BPH). Conventionally, two known etiological factors for the development of BPH have been aging and the presence of functional testes. Assignment of these two factors, although reasonable, has not been conducive to aid the research community to identify and isolate the patho-physiological agents that are directly responsible for the development of this disease. In the present review, we proposed a broadened concept of intrinsic and extrinsic factors for BPH. This concept offers identifiable research opportunities that will facilitate our quest in search for etiological agents for BPH. A brief description of various intrinsic and extrinsic factors and justifications for their selection will be discussed.

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
Issue number2
StatePublished - May 1 1997


  • environmental factors
  • genetic factors
  • non-testicular factors
  • stromal-epithelial interaction
  • testicular factors

ASJC Scopus subject areas

  • Oncology
  • Urology


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