Intrinsic network activity in tinnitus investigated using functional MRI

Amber M. Leaver*, Ted K. Turesky, Anna Seydell-Greenwald, Susan Morgan, Hung J. Kim, Josef P. Rauschecker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Tinnitus is an increasingly common disorder in which patients experience phantom auditory sensations, usually ringing or buzzing in the ear. Tinnitus pathophysiology has been repeatedly shown to involve both auditory and non-auditory brain structures, making network-level studies of tinnitus critical. In this magnetic resonance imaging (MRI) study, two resting-state functional connectivity (RSFC) approaches were used to better understand functional network disturbances in tinnitus. First, we demonstrated tinnitus-related reductions in RSFC between specific brain regions and resting-state networks (RSNs), defined by independent components analysis (ICA) and chosen for their overlap with structures known to be affected in tinnitus. Then, we restricted ICA to data from tinnitus patients, and identified one RSN not apparent in control data. This tinnitus RSN included auditory–sensory regions like inferior colliculus and medial Heschl's gyrus, as well as classically non-auditory regions like the mediodorsal nucleus of the thalamus, striatum, lateral prefrontal, and orbitofrontal cortex. Notably, patients' reported tinnitus loudness was positively correlated with RSFC between the mediodorsal nucleus and the tinnitus RSN, indicating that this network may underlie the auditory–sensory experience of tinnitus. These data support the idea that tinnitus involves network dysfunction, and further stress the importance of communication between auditory–sensory and fronto-striatal circuits in tinnitus pathophysiology. Hum Brain Mapp 37:2717–2735, 2016.

Original languageEnglish (US)
Pages (from-to)2717-2735
Number of pages19
JournalHuman Brain Mapping
Volume37
Issue number8
DOIs
StatePublished - Aug 1 2016

Keywords

  • auditory
  • fMRI
  • functional connectivity
  • hearing loss
  • striatum
  • thalamus

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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